ウスバサイシンの市販品と栽培品中のアリストロキア酸の分析

Abstract

We investigated by HPLC the content of aristolochic acid I, a nephrotoxic and carcinogenic ingredient in commercial Asiasarum siebldii, Asiasarum siebldii cultivated in the greenhouse, Asiasarum siebldii cultivated in the plant factory under LED light, and pharmacopoeial asiasarum root. Aristolochic acid I content in aerial parts in commercial plants (6 products), the greenhouse cultivated plants (n = 3) and the plant factory cultivated plants under LED light (n = 3) was 8.9～84, 8.0 and 27 μg/g in average respectively, while aristolochic acid I was not detected in these underground parts and pharmacopoeial asiasarum root. According to clinical finding, aristolochic acid caused nephropathy in humans at the range of 3.1～233 μg/g in Chinese herbs, health foods and others. Therefore, the use of the aerial parts of Asiasarum sieboldii should be avoided to prevent the risk of health hazard.