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Please use this identifier to cite or link to this item: http://hdl.handle.net/11173/1761

Title: ヒト外分泌液中の食品タンパク質特異的IgAおよびその免疫複合体
Other Titles: Food protein-specific IgAs and their immune complexes in human exocrine fluids
Authors: 木津, 久美子
Kizu, Kumiko
廣瀬, 潤子
Hirose, Junko
山口(村上), 友貴絵
Murakami-Yamaguchi, Yukie
木村, 彰宏
Kimura, Akihiro
成田, 宏史
Narita, Hiroshi
Issue Date: 25-Dec-2010
Publisher: 京都女子大学食物学会
Abstract: We have revealed the occurrence of food proteins as immune complexes in human breast milk. In this report, we aimed to establish the generality of the fact in human exocrine fluids by analyzing food proteinspecific IgAs and their immune complexes in human saliva and tear. Food protein-specific IgAs and their immune complexes were able to be determined in human saliva and tear. The levels were high in order of nursing mothers, adults, and infants. There was no correlation between total IgA and specific IgAs. On the other hand, negative correlation between serum IgE and salivary IgA specific to egg white proteins was observed in infants with atopic eczema. Then, it was suggested that the degree of maturation of mucosal immunity in individual person could be monitored as the anti-allergic parameter by analyzing food protein-specific IgAs in saliva. Saliva can be easily prepared without pain and prick. Utility of saliva as a biological material for clinical diagnosis and physiological significance of the food protein-IgA immune complexes in exocrine fluids were proposed
URI: http://hdl.handle.net/11173/1761
Appears in Collections:第65号(2010-12-25)

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