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Please use this identifier to cite or link to this item: http://hdl.handle.net/11173/122

Title: 転写方程式の分子論的解釈
Other Titles: Molecular Interpretation of Equation for Transcription
Authors: 宮田, 堅司
Miyata, Kenji
Keywords: 転写
力学モデル
転写方程式
マウス胸腺
インターロイキン
Issue Date: 31-Jan-2013
Publisher: 京都女子大学食物学会
Abstract: Considering the molecular mechanism, the equation for transcription, which describes the ratio of anygene-transcripts, is derived. RNA polymerase II moves from transcriptional starting point along a gene underaccelerative force F and resistant forces, both a frictional -rx˙ and -sx proportional to traveling distance x. Thenthe equation of motion of RNA polymerase II may be represented by the following, mx¨ = F - rx˙ - sx. In thisequation x, which means traveling distance of polymerase, may be considered as quantity of transcript, and that of inner standard gene is taken to be equal to unit, so that x can be regarded as the ratio of two gene-transcripts.Arranging the coefficients, the equation for transcription x¨ + 2ax˙ + bx = bD is obtained, where a = r/2m isexpected to be constant for any cases and D = F/bm to be almost same value for similar genes of same kinds ofcell. These predictions are examined for 9 kinds of interleukin.
URI: http://hdl.handle.net/11173/122
Appears in Collections:第67号(2013-01-31)

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