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Please use this identifier to cite or link to this item: http://hdl.handle.net/11173/1897

Title: 転写現象の方程式
Other Titles: Equation for Transcription
Authors: 野々垣, 智美
Nonogaki, Tomomi
森瀬, 美由紀
Morise, Miyuki
近藤, 芙美
Kondou, Fumi
須田, 温子
Suda, Atsuko
長尾, 香奈
Nagao, Kana
長谷川, 千幸
Hasegawa, Chiyuki
廣瀬, 友紀
Hirose, Yuki
藤井, 愛美
Fujii, Megumi
宮田, 堅司
Miyata, Kenji
Issue Date: 13-Jan-2012
Publisher: 京都女子大学食物学会
Abstract: The ratio of some gene-transcripts in the thymus of mouse had a maximum with aging. A second order differential equation, x + 2 ak+ bx = bD , could be used to analyze such measurements. This equation resembled one used in a damped harmonic oscillator, then, it was supposed that the quantities of transcripts increased and decreased repeatedly in time-course under the influence of some factors. The general solution of abovementioned differential equation took the form x = Ce^-a1 cos( √<b-a^2>t + β)+ D in the case of b —a ^2>0 or x - Ae^-(a+√<a^e-b>)t + B e^-(a-√<a^2-b>)t + D in b — a^ 2 < 0. The ratios of interleukin2(IL2),4(IL4), T cell receptor fl-chain(TCRβ), immunoglobulin E(IgE) and M(IgM)-transcripts were measured in the thymus of mice by realtime PCR. LogIL4/TCRβ and logIgE/IgM increased rapidly from birth to about 50 days and then decreased, namely had maximums. Otherwise, logIL2/ TCRβ increased slightly after birth and remained constantly. The calculated values by the equation using adequate parameters were in fair agreement with those measured
URI: http://hdl.handle.net/11173/1897
Appears in Collections:第66号(2012-01-13)

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