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Please use this identifier to cite or link to this item: http://hdl.handle.net/11173/1895

Title: マウス抗体クラススィッチ過程の速度論に基づく解析
Other Titles: Analysis for the Class Switching Process of mouse by Rate Theory
Authors: 宮田, 堅司
Miyata, Kenji
Issue Date: 13-Jan-2012
Publisher: 京都女子大学食物学会
Abstract: The class-switching process of immunoglobulin(Ig) gene-transcribing cells was investigated in the thymus of BALB/c female mice. The ratios of IgM,IgG1,IgG3 and IgE-transcripts were determined with aging by realtime PCR. Logarithmic values of IgG1/1gM and IgG3/IgM increased rapidly from birth to several weeks and then gradually. While that of IgE/IgM increased similarly to about 7.5 weeks and it decreased afterwards. Rate theory was applied to analyze these results with supposing both that transcript-quantity was proportional to the number of transcribing cells and that IgM-transcribing cells were supplied continually from stem cells in vivo. On the first order differential concurrent model, in which IgM cells recombined Ig genes and changed to other Ig class-transcribing with rate constants k, the rate equations were solved theoretically. The calculated values of logIgGl/IgM and logIgG3/IgM were good agreement with experimental ones for periods up to 400 days after birth. But, in the case of logIgE/IgM, which had a maximum, this theory could not agree the maximum value
URI: http://hdl.handle.net/11173/1895
Appears in Collections:第66号(2012-01-13)

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