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第63号(2008-12-11) >

Please use this identifier to cite or link to this item: http://hdl.handle.net/11173/1890

Title: 抗体クラススィッチ過程の活性化自由エネルギー
Other Titles: Free Energy of Activation in vivo for the Class Switch Process of Antibody
Authors: 犬竹, 真奈美
Inutake, Manami
梶谷, 奈央
Kajitani, Nao
高橋, 知実
Takahashi, Tomomi
富永, 佳央理
Tominaga, Kaori
仲林, 祐衣
Nakabayashi, Yui
藤本, 真代
Fujimoto, Mayo
山戸, 美幸
Yamato, Miyuki
宮田, 堅司
Miyata, Kenji
Issue Date: 11-Dec-2008
Publisher: 京都女子大学食物学会
Abstract: Membrane-bound form IgM (IgM_m) and total IgM (IgM_t) transcriptions were measured by real time PCR method in the thymus and the spleen of BALB/c male mice and the change of logIgMmagMt ratios with age were detected. Kinetics was applied and both the rate constant k_1, corresponding to the process in which IgM_mtranscribing cells differentiate into ones transcribing secretory type IgM and k_2, corresponding to the process in which those into cells transcribing other class Ig, were determined. ΔG_1^* and ΔG_2^*, free energy of activation corresponding to k_1 and k_2 process in each, were calculated from k_1 and k_2 by application of theory of absolute reaction rate. ΔG_1^* and ΔG_2^* were 110 to 120 kJ/mol both in the thymus and in the spleen. By considering the phenomenal differences in k_1 and k_2 processes, the difference of ΔG_2^* and ΔG_1^* might be able to regard as the free energy of immunoglobulin class switch process ΔG_c^* . The values of ΔG_c^* were small unexpectedly, 2. 9 kJ/mol in the thymus and 5. 7 kJ/mol in the spleen.
URI: http://hdl.handle.net/11173/1890
Appears in Collections:第63号(2008-12-11)

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