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第54号(1999-12-10) >

Please use this identifier to cite or link to this item: http://hdl.handle.net/11173/1384

Title: アスコルビン酸ステアリン酸エステルを投与したマウスにおける鉛毒性の軽減
Other Titles: Ameliorative effect of ascorbyl stearate ester-feeding on lead toxicity in mice
Authors: 植木, 芽美
Ueki, Megumi
山中, 美幸
Yamanaka, Miyuki
綿貫, 靖子
Watanuki, Yasuko
滝本, 恭子
Takimoto, Kyoko
松倉, 理恵
Matukura, Rie
岡本, 麻友子
Okamoto, Mayuko
毛利, 友美
Mohri, Tomomi
中川, 一夫
Nakagawa, Kazuo
Issue Date: 10-Dec-1999
Publisher: 京都女子大学食物学会
Abstract: We aimed to evaluate roles of hepatic ascorbic acid in ddY strain mice after a single injection of lead acetate (100μmol/kg body weight, i.p.). Lead decreased glutathione content, inhibited glutathione S-transferase activity, and increased calcium content in the liver four days after the injection. These lead-induced alterations were significantly antagonized by the treatment of mice with a diet containing 1(w/w) % ascorbyl stearate ester (ASE) for three days before and four days after lead injection, whereas ascorbate content was largely elevated in the livers of animals treated with both lead and ASE. Furthermore, the production of NADPH was enhanced by not only lead injection but also ASE-feeding. These results suggest that ASE-feeding could ameliorate cell damage through the restoration of intracellular redox states.
URI: http://hdl.handle.net/11173/1384
Appears in Collections:第54号(1999-12-10)

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