DSpace コレクション: 2008-12-112008-12-11http://hdl.handle.net/11173/16892024-03-28T15:08:49Z2024-03-28T15:08:49Z抗体クラススィッチ過程の活性化自由エネルギー犬竹, 真奈美Inutake, Manami梶谷, 奈央Kajitani, Nao高橋, 知実Takahashi, Tomomi富永, 佳央理Tominaga, Kaori仲林, 祐衣Nakabayashi, Yui藤本, 真代Fujimoto, Mayo山戸, 美幸Yamato, Miyuki宮田, 堅司Miyata, Kenjihttp://hdl.handle.net/11173/18902015-03-12T05:19:36Z2008-12-10T15:00:00Zタイトル: 抗体クラススィッチ過程の活性化自由エネルギー
著者: 犬竹, 真奈美; Inutake, Manami; 梶谷, 奈央; Kajitani, Nao; 高橋, 知実; Takahashi, Tomomi; 富永, 佳央理; Tominaga, Kaori; 仲林, 祐衣; Nakabayashi, Yui; 藤本, 真代; Fujimoto, Mayo; 山戸, 美幸; Yamato, Miyuki; 宮田, 堅司; Miyata, Kenji
抄録: Membrane-bound form IgM (IgM_m) and total IgM (IgM_t) transcriptions were measured by real time PCR method in the thymus and the spleen of BALB/c male mice and the change of logIgMmagMt ratios with age were detected. Kinetics was applied and both the rate constant k_1, corresponding to the process in which IgM_mtranscribing cells differentiate into ones transcribing secretory type IgM and k_2, corresponding to the process in which those into cells transcribing other class Ig, were determined. ΔG_1^* and ΔG_2^*, free energy of activation corresponding to k_1 and k_2 process in each, were calculated from k_1 and k_2 by application of theory of absolute reaction rate. ΔG_1^* and ΔG_2^* were 110 to 120 kJ/mol both in the thymus and in the spleen. By considering the phenomenal differences in k_1 and k_2 processes, the difference of ΔG_2^* and ΔG_1^* might be able to regard as the free energy of immunoglobulin class switch process ΔG_c^* . The values of ΔG_c^* were small unexpectedly, 2. 9 kJ/mol in the thymus and 5. 7 kJ/mol in the spleen.2008-12-10T15:00:00Zヨウ素過剰摂取による一過性甲状腺機能異常田中, 清Tanaka, Kiyoshihttp://hdl.handle.net/11173/18892015-03-12T05:20:37Z2008-12-10T15:00:00Zタイトル: ヨウ素過剰摂取による一過性甲状腺機能異常
著者: 田中, 清; Tanaka, Kiyoshi
抄録: Iodine deficiency affects almost one billion of people worldwide, and is by far the leading cause of hypothyroidism. Japan is unique in that there are no single patients with hypothyroidism due to nutritional iodine deficiency. Thyroid abnormalities induced by excessive iodine intake, however, is not infrequent in Japan. We report here a case of young woman with severe hypothyroidism. Symptoms such as weight gain, edema, amenorrhea, and constipation were accompanied. She had habitual excessive iodine intake, with the cessation of which her thyroid abnormalities as well as her symptoms subsided. Iodine exerts biphasic effects on the thyroid gland. Its deficiency results in diminished thyroid hormone synthesis ; hence hypothyroidism, since thyroid hormones are iodine-containing amino acids. Its excess inhibits practically all functional aspects of thyroid gland ; iodine uptake from circulation, thyroid hormone synthesis, and its secretion to bloodstream. What makes the matter more perplexing is the fact that the detrimental effect of excess iodine is much more likely to occur in those with pre-existing thyroid disease, even in the mild form. Furthermore, every one or two women out of ten have thyroid diseases such as chronic thyroiditis. Thus supplementation with iodine is by no means encouraged in Japan. Dietitians must be aware of the unique feature of iodine status in Japan.2008-12-10T15:00:00Z管理栄養士養成課程における給食経営管理実習の試み : 原価管理, 衛生管理, 労務管理に焦点をあてて桂(橘高), 博美Kittaka-Katsura, Hiromi河野, 篤子Kouno, Atsukohttp://hdl.handle.net/11173/18882020-07-22T06:53:39Z2008-12-10T15:00:00Zタイトル: 管理栄養士養成課程における給食経営管理実習の試み : 原価管理, 衛生管理, 労務管理に焦点をあてて
著者: 桂(橘高), 博美; Kittaka-Katsura, Hiromi; 河野, 篤子; Kouno, Atsuko
抄録: A training course entitled, "Food service systems management practice", for student dietitians has been offered at Kyoto Women's University since 2004. This course focuses on the following three areas of management : financial, hygiene and personnel managements. We conducted a questionnaire survey of students who took the course to assess whether they could understand the three areas of management. Their answers on the questionnaire were scored by us. Moreover, we graded reports that had been written by the students in the course, out of a score of 5. We compared the scores on the questionnaires and the scores on their reports, and found that they were not consistent. About 30% of the students wrote that there was not enough communication among the students. Therefore, communication was one of the most important tools for their recognition of the importance of financial, hygiene, and personnel managements.; 平成14年度に改定された管理栄養士養成課程の新しいカリキュラムにおいて,「給食管理」は,「給食経営管理論」へと内容の充実が図られた。それに伴い,講義・実習内容を見直すことになった。我々は, 平成16年度にはじめて「給食経営管理実習」を行った。当該の実習では,原価管理・衛生管理・労務管理についてマネジメントサイクルを用いて業務を遂行するように計画し,実習を行っている。今回は, 平成16年度と平成17年度に行われた実習について実習終了後に学生にアンケートを行い,教員が報告書の評価を行って結果を比較し,3つの管理項目に対する学生の理解について検討した。 その結果,教員の評価は3つの管理項目のうち原価管理が最も低く,衛生管理が最も高くなったが, 学生のアンケートへの記載内容は逆であった。これは,報告書の完成度は高いが,衛生管理に携わった学生が局所的であり,その情報は班内で共有されなかったと解釈された。また,班内における情報交換の重要性を30%以上の学生が述べており,この実習で焦点をあてた原価管理・衛生管理・労務管理の理解には学生間の情報交換が最も重要であることが示された。2008-12-10T15:00:00Z表紙ほかhttp://hdl.handle.net/11173/17932015-02-24T16:30:18Z2008-12-10T15:00:00Zタイトル: 表紙ほか2008-12-10T15:00:00Z